Mater.Phys.Mech.(MPM)
No 5, Vol. 42, 2019, pages 625-636

HEATING AND DESTRUCTION OF BIOLOGICAL TISSUE BY HIGH-INENSITY
FOCUSED ULTRASOUND

T.A. Andreeva, A.E. Berkovich, N.Y. Bykov, S.V. Kozyrev, A.Ya. Lukin

Abstract

Processes of heating and destruction of the breast fat tissue under the action of focused high-intensity ultrasound generated by a 128-element transducer are considered. The simulation of a thermal problem is carried out by anumerical solution of the heat transfer equation. The acoustic pressure field in the tissue is calculated using the Rayleigh integral. A system of dimensionless scaling parameters is proposed to describe the non-stationary process of heat propagation. The influenceof the space localization of foci in a series of pulses on the lesion size is analyzed. The results demonstrate the advantages of a tissue processing program withspatially divergingfocal points of pulses, consisting in a more uniform heating of the tissue and the formation of a continuous ablation area. The impact of the perfusion process on the lesion size is considered.

Keywords: high-intensity focused ultrasound, tumor ablation, heat transfer equation, heat propagation in tissue

full paper (pdf, 2560 Kb)